Research Papers

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A "clickable" MTX reagent as a practical tool for profiling small-molecule-intracellular target interactions via MASPIT.
Risseeuw MD; De Clercq DJ; Lievens S; Hillaert U; Sinnaeve D; Van den Broeck F; Martins JC; Tavernier J; Van Calenbergh S.
ChemMedChem (Unknown)
Published: 2013
Identification of drugs inducing phospholipidosis by novel in vitro data.
Muehlbacher M; Tripal P; Roas F; Kornhuber J.
ChemMedChem (Unknown)
Published: 2012
1/6 Transparent
Funding Declared
Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors o…
Reddy TR; Li C; Fischer PM; Dekker LV.
ChemMedChem (Unknown)
Published: 2012
1/6 Transparent
Funding Declared
Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with c…
Dietz M; Mohr P; Kuhn B; Maerki HP; Hartman P; Ruf A; Benz J; Grether U; Wright MB.
ChemMedChem (Unknown)
Published: 2012
2/6 Transparent
Funding Declared
Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and…
Wacker SJ; Jurkowski W; Simmons KJ; Fishwick CW; Johnson AP; Madge D; Lindahl E; Rolland JF; de Groot BL.
ChemMedChem (Unknown)
Published: 2012
1/6 Transparent
Funding Declared
Investigation of D₁ receptor-agonist interactions and D₁/D₂ agonist selectivity using a combination of pharmacophore an…
Malo M; Brive L; Luthman K; Svensson P.
ChemMedChem (Unknown)
Published: 2012
1/6 Transparent
Funding Declared
Investigation of D₂ receptor-agonist interactions using a combination of pharmacophore and receptor homology modeling.
Malo M; Brive L; Luthman K; Svensson P.
ChemMedChem (Unknown)
Published: 2012
1/6 Transparent
Funding Declared
Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).
Woo LW; Ganeshapillai D; Thomas MP; Sutcliffe OB; Malini B; Mahon MF; Purohit A; Potter BV.
ChemMedChem (Unknown)
Published: 2011
2/6 Transparent
Data Funding Declared
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
Cleghorn LA; Woodland A; Collie IT; Torrie LS; Norcross N; Luksch T; Mpamhanga C; Walker RG; Mottram JC; Brenk R; Frearson JA; Gilbert IH; Wyatt PG.
ChemMedChem (Unknown)
Published: 2011
1/6 Transparent
Funding Declared
Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.
Smith VC; Cleghorn LA; Woodland A; Spinks D; Hallyburton I; Collie IT; Mok NY; Norval S; Brenk R; Fairlamb AH; Frearson JA; Read KD; Gilbert IH; Wyatt PG.
ChemMedChem (Unknown)
Published: 2011
1/6 Transparent
Funding Declared
Identification of small-molecule inhibitors of the XendoU endoribonucleases family.
Ragno R; Gioia U; Laneve P; Bozzoni I; Mai A; Caffarelli E.
ChemMedChem (Unknown)
Published: 2011
1/6 Transparent
Funding Declared
PET imaging of CXCR4 receptors in cancer by a new optimized ligand.
Demmer O; Gourni E; Schumacher U; Kessler H; Wester HJ.
ChemMedChem (Unknown)
Published: 2011
1/6 Transparent
Funding Declared
Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.
Wood PM; Woo LW; Thomas MP; Mahon MF; Purohit A; Potter BV.
ChemMedChem (Unknown)
Published: 2011
1/6 Transparent
Funding Declared
Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Su X; Vicker N; Thomas MP; Pradaux-Caggiano F; Halem H; Culler MD; Potter BV.
ChemMedChem (Unknown)
Published: 2011
1/6 Transparent
Funding Declared
Thiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.
Pinson JA; Schmidt-Kittler O; Zhu J; Jennings IG; Kinzler KW; Vogelstein B; Chalmers DK; Thompson PE.
ChemMedChem (Unknown)
Published: 2011
2/6 Transparent
Data Funding Declared
A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite.
Mahajan SS; Deu E; Lauterwasser EM; Leyva MJ; Ellman JA; Bogyo M; Renslo AR.
ChemMedChem (Unknown)
Published: 2011
Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei.
Ehmke V; Heindl C; Rottmann M; Freymond C; Schweizer WB; Brun R; Stich A; Schirmeister T; Diederich F.
ChemMedChem (Unknown)
Published: 2010
2/6 Transparent
Data Funding Declared
Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.
Richardson JL; Nett IR; Jones DC; Abdille MH; Gilbert IH; Fairlamb AH.
ChemMedChem (Unknown)
Published: 2009
1/6 Transparent
Funding Declared
Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.
Brenk R; Schipani A; James D; Krasowski A; Gilbert IH; Frearson J; Wyatt PG.
ChemMedChem (Unknown)
Published: 2008
1/6 Transparent
Funding Declared
Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial.
Dive D; Biot C.
ChemMedChem (Unknown)
Published: 2008
Rapid synthesis of iminosugar derivatives for cell-based in situ screening: discovery of "hit" compounds with anticance…
Zhang L; Sun F; Li Y; Sun X; Liu X; Huang Y; Zhang LH; Ye XS; Xiao J.
ChemMedChem (Unknown)
Published: 2007
1/6 Transparent
Funding Declared
Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-ph…
Ruda GF; Alibu VP; Mitsos C; Bidet O; Kaiser M; Brun R; Barrett MP; Gilbert IH.
ChemMedChem (Unknown)
Published: 2007
1/6 Transparent
Funding Declared