Research Papers

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Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.
Dal Maso E; Zhu Y; Pham V; Reynolds CA; Deganutti G; Hick CA; Yang D; Christopoulos A; Hay DL; Wang MW; Sexton PM; Furness SGB; Wootten D.
Biochem Pharmacol (Unknown)
Published: 2018
2/6 Transparent
Funding Declared
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using …
Cobice DF; Livingstone DEW; McBride A; MacKay CL; Walker BR; Webster SP; Andrew R.
Biochem Pharmacol (Unknown)
Published: 2017
2/6 Transparent
Funding Declared
Characterisation of endogenous A<sub>2A</sub> and A<sub>2B</sub> receptor-mediated cyclic AMP responses in HEK 293 cell…
Goulding J; May LT; Hill SJ.
Biochem Pharmacol (Unknown)
Published: 2017
2/6 Transparent
Funding Declared
A monoclonal antibody raised against a thermo-stabilised β<sub>1</sub>-adrenoceptor interacts with extracellular loop 2…
Soave M; Cseke G; Hutchings CJ; Brown AJH; Woolard J; Hill SJ.
Biochem Pharmacol (Unknown)
Published: 2017
2/6 Transparent
Funding Declared
A partnership with the proteasome; the destructive nature of GSK3.
Robertson H; Hayes JD; Sutherland C.
Biochem Pharmacol (Unknown)
Published: 2017
1/6 Transparent
Funding Declared
Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models.
Gastaldello A; Livingstone DE; Abernethie AJ; Tsang N; Walker BR; Hadoke PW; Andrew R.
Biochem Pharmacol (Unknown)
Published: 2017
2/6 Transparent
Funding Declared
High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH<sub>2</sub>) receptor requires th…
Weaver RE; Mobarec JC; Wigglesworth MJ; Reynolds CA; Donnelly D.
Biochem Pharmacol (Unknown)
Published: 2016
1/6 Transparent
Funding Declared
Antivirals against animal viruses.
Villa TG; Feijoo-Siota L; Rama JLR; Ageitos JM.
Biochem Pharmacol (Unknown)
Published: 2016
Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists.
Caseley EA; Muench SP; Fishwick CW; Jiang LH.
Biochem Pharmacol (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
A novel real time imaging platform to quantify macrophage phagocytosis.
Kapellos TS; Taylor L; Lee H; Cowley SA; James WS; James WS; Iqbal AJ; Greaves DR.
Biochem Pharmacol (Unknown)
Published: 2016
3/6 Transparent
Data Funding Declared
Cardiac action of the first G protein biased small molecule apelin agonist.
Read C; Fitzpatrick CM; Yang P; Kuc RE; Maguire JJ; Glen RC; Foster RE; Davenport AP.
Biochem Pharmacol (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells.
Wirrig C; McKean JS; Wilson HM; Nixon GF.
Biochem Pharmacol (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.
Zhang Y; Colenso CK; El Harchi A; Cheng H; Witchel HJ; Dempsey CE; Hancox JC.
Biochem Pharmacol (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
Vaccine technologies: From whole organisms to rationally designed protein assemblies.
Karch CP; Burkhard P.
Biochem Pharmacol (Unknown)
Published: 2016
1/6 Transparent
Funding Declared
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precisi…
Leus NG; van der Wouden PE; van den Bosch T; Hooghiemstra WTR; Ourailidou ME; Kistemaker LE; Bischoff R; Gosens R; Haisma HJ; Dekker FJ.
Biochem Pharmacol (Unknown)
Published: 2016
1/6 Transparent
Funding Declared
Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell de…
Koyani CN; Kitz K; Rossmann C; Bernhart E; Huber E; Trummer C; Windischhofer W; Sattler W; Malle E.
Biochem Pharmacol (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic agein…
Gonzalez Malagon SG; Melidoni AN; Hernandez D; Omar BA; Houseman L; Veeravalli S; Scott F; Varshavi D; Everett J; Tsuchiya Y; Timms JF; Phillips IR; Shephard EA.
Biochem Pharmacol (Unknown)
Published: 2015
1/6 Transparent
Funding Declared
MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical eff…
Barrington RD; Needs PW; Williamson G; Kroon PA.
Biochem Pharmacol (Unknown)
Published: 2015
2/6 Transparent
Data Funding Declared
Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin.
Üllen A; Nusshold C; Glasnov T; Saf R; Cantillo D; Eibinger G; Reicher H; Fauler G; Bernhart E; Hallstrom S; Kogelnik N; Zangger K; Oliver Kappe C; Malle E; Sattler W.
Biochem Pharmacol (Unknown)
Published: 2015
1/6 Transparent
Funding Declared
Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells.
Wiggins HL; Wymant JM; Solfa F; Hiscox SE; Taylor KM; Westwell AD; Jones AT.
Biochem Pharmacol (Unknown)
Published: 2014
1/6 Transparent
Funding Declared
Ebola virus (EBOV) infection: Therapeutic strategies.
De Clercq E.
Biochem Pharmacol (Unknown)
Published: 2014
Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.
Fujita W; Gomes I; Dove LS; Prohaska D; McIntyre G; Devi LA.
Biochem Pharmacol (Unknown)
Published: 2014
1/6 Transparent
Funding Declared
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
Wang L; Waltenberger B; Pferschy-Wenzig EM; Blunder M; Liu X; Malainer C; Blazevic T; Schwaiger S; Rollinger JM; Heiss EH; Schuster D; Kopp B; Bauer R; Stuppner H; Dirsch VM; Atanasov AG.
Biochem Pharmacol (Unknown)
Published: 2014
1/6 Transparent
Funding Declared
Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through su…
Zhao Z; Tang X; Zhao X; Zhang M; Zhang W; Hou S; Yuan W; Zhang H; Shi L; Jia H; Liang L; Lai Z; Gao J; Zhang K; Fu L; Chen W.
Biochem Pharmacol (Unknown)
Published: 2014
1/6 Transparent
Funding Declared
Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: e…
Wlcek K; Hofstetter L; Stieger B.
Biochem Pharmacol (Unknown)
Published: 2014
1/6 Transparent
Funding Declared