Large tandem chromosome expansions facilitate niche adaptation during persistent infection with drug-resistant <i>Staphylococcus aureus</i>.

"keywords: staphylococcus aureus antibiotic resistance chromosome duplication genomics mutation evolution abbreviations: hvisa heterogeneous vancomycin-intermediate staphylococcus aureus mrsa meticillin-resistant staphylococcus aureus msc minimal selective concentration qpcr quantitative pcr scv small colony variant snp single nucleotide polymorphism vssa vancomycin-sensitive staphylococcus aureus supplementary table s4 is available through figshare http://dx doi org/10 6084/m9 figshare 1394626 (2015) table s4 complete genome sequences available through figshare pending genbank release: http://dx doi org/10 6084/m9 figshare 1391325 (2015) jkd6229 gb http://dx doi org/10 6084/m9 figshare 1391322 (2015) jkd6210 gb http://dx doi org/10 6084/m9 figshare 1391323 (2015) jkd6210p gb software used available through github https://github com/tseemann/prokka (2015) and http://www vicbioinformatics com/software shtml sequence read data for the study isolates have been submitted to the embl sequence read archive (ena) http://www ebi ac uk/ena/data/view/erp010276 bacterial antibiotic resistance is an increasingly serious global problem. keywords: staphylococcus aureus antibiotic resistance chromosome duplication genomics mutation evolution abbreviations: hvisa heterogeneous vancomycin-intermediate staphylococcus aureus mrsa meticillin-resistant staphylococcus aureus msc minimal selective concentration qpcr quantitative pcr scv small colony variant snp single nucleotide polymorphism vssa vancomycin-sensitive staphylococcus aureus supplementary table s4 is available through figshare http://dx doi org/10 6084/m9 figshare 1394626 (2015) table s4 complete genome sequences available through figshare pending genbank release: http://dx doi org/10 6084/m9 figshare 1391325 (2015) jkd6229 gb http://dx doi org/10 6084/m9 figshare 1391322 (2015) jkd6210 gb http://dx doi org/10 6084/m9 figshare 1391323 (2015) jkd6210p gb software used available through github https://github com/tseemann/prokka (2015) and http://www vicbioinformatics com/software shtml sequence read data for the study isolates have been submitted to the embl sequence read archive (ena) http://www ebi ac uk/ena/data/view/erp010276 bacterial antibiotic resistance is an increasingly serious global problem. keywords: staphylococcus aureus antibiotic resistance chromosome duplication genomics mutation evolution abbreviations: hvisa heterogeneous vancomycin-intermediate staphylococcus aureus mrsa meticillin-resistant staphylococcus aureus msc minimal selective concentration qpcr quantitative pcr scv small colony variant snp single nucleotide polymorphism vssa vancomycin-sensitive staphylococcus aureus supplementary table s4 is available through figshare http://dx doi org/10 6084/m9 figshare 1394626 (2015) table s4 complete genome sequences available through figshare pending genbank release: http://dx doi org/10 6084/m9 figshare 1391325 (2015) jkd6229 gb http://dx doi org/10 6084/m9 figshare 1391322 (2015) jkd6210 gb http://dx doi org/10 6084/m9 figshare 1391323 (2015) jkd6210p gb software used available through github https://github com/tseemann/prokka (2015) and http://www vicbioinformatics com/software shtml sequence read data for the study isolates have been submitted to the embl sequence read archive (ena) http://www ebi ac uk/ena/data/view/erp010276 bacterial antibiotic resistance is an increasingly serious global problem."

"keywords: staphylococcus aureus antibiotic resistance chromosome duplication genomics mutation evolution abbreviations: hvisa heterogeneous vancomycin-intermediate staphylococcus aureus mrsa meticillin-resistant staphylococcus aureus msc minimal selective concentration qpcr quantitative pcr scv small colony variant snp single nucleotide polymorphism vssa vancomycin-sensitive staphylococcus aureus supplementary table s4 is available through figshare http://dx doi org/10 6084/m9 figshare 1394626 (2015) table s4 complete genome sequences available through figshare pending genbank release: http://dx doi org/10 6084/m9 figshare 1391325 (2015) jkd6229 gb http://dx doi org/10 6084/m9 figshare 1391322 (2015) jkd6210 gb http://dx doi org/10 6084/m9 figshare 1391323 (2015) jkd6210p gb software used available through github https://github com/tseemann/prokka (2015) and http://www vicbioinformatics com/software shtml sequence read data for the study isolates have been submitted to the embl sequence read archive (ena) http://www ebi ac uk/ena/data/view/erp010276 bacterial antibiotic resistance is an increasingly serious global problem. keywords: staphylococcus aureus antibiotic resistance chromosome duplication genomics mutation evolution abbreviations: hvisa heterogeneous vancomycin-intermediate staphylococcus aureus mrsa meticillin-resistant staphylococcus aureus msc minimal selective concentration qpcr quantitative pcr scv small colony variant snp single nucleotide polymorphism vssa vancomycin-sensitive staphylococcus aureus supplementary table s4 is available through figshare http://dx doi org/10 6084/m9 figshare 1394626 (2015) table s4 complete genome sequences available through figshare pending genbank release: http://dx doi org/10 6084/m9 figshare 1391325 (2015) jkd6229 gb http://dx doi org/10 6084/m9 figshare 1391322 (2015) jkd6210 gb http://dx doi org/10 6084/m9 figshare 1391323 (2015) jkd6210p gb software used available through github https://github com/tseemann/prokka (2015) and http://www vicbioinformatics com/software shtml sequence read data for the study isolates have been submitted to the embl sequence read archive (ena) http://www ebi ac uk/ena/data/view/erp010276 bacterial antibiotic resistance is an increasingly serious global problem."

"This research was supported by the National Health and Medical Research Council (NHMRC) of Australia (1008973). B. P. H. and T. P. S. are recipients of NHMRC fellowships (1023526 and 1008549, respectively). S. G. and T. S. were supported in part by the VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and La Trobe Universities, and an initiative of the Victorian Government, Australia."