The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism.

"Competing interests: All authors declare no competing interests."

"We thank members of the Sheng lab for constructive discussion; K. A. Chamberlain and J. C. Roney for critical reading and editing; K. Remmert and J. Hammer (NHLBI, NIH) for advice on actin co-sedimentation assay; H. Imamura (Kyoto University), R. Youle (NINDS, NIH), J. Hammer (NHLBI, NIH), J. Kendrick-Jones (MRC-LMB), F. Buss (University of Cambridge), D-Y. Jin (The University of Hong Kong), G. Voeltz (University of Colorado), M. Matsuda (Kyoto University) and D. Trono (EPFL) for sharing constructs; and the NINDS EM Facility and Light Imaging Facility. This work was supported by the Intramural Research Program of NINDS, NIH ZIA NS003029, and ZIA NS002946 (Z-H. Sheng)."