Tetracyclines promote survival and fitness in mitochondrial disease models.

"chemical screen data has been deposited in pubchem with accession dataset identifier 1508586 and proteomic data in pride with accession dataset identifier pxd022860."

"Competing interests: The authors declare no competing interests."

"We thank members of the Puigserver Laboratory for helpful discussions regarding this project. We would like to thank A. Renner of the Myers lab for careful editing of the manuscript. We would like to thank C. Moraes (University of Miami Medical School) and J. Smeitink and R. Vogel (Radboud University Medical Centre, Nijmegen, Gelderlan, Netherlands) for providing us with the cell lines used in this study. Also, we would like to acknowledge the Nikon Imaging Center at Harvard Medical School for assistance with brightfield microscopy, the ICCB-Longwood Screening Facility at Harvard Medical School for facilitating our screening efforts, J.M. Asara and M. Yuan at the Beth Israel Deaconess Medical Center Mass Spectrometry Core for providing metabolomics profiling data, R. Bronson and the Rodent Histopathology Core at Harvard Medical School for careful sectioning and analysis of mouse sections and well as the Specialized Histopathology Core at Brigham and Women’s Hospital for immunohistochemistry. We would like to thank C. Vidoudez of the Harvard Center for Mass Spectrometry for analysis of doxycycline tissue concentrations. This work was supported by NIH RO1 DK089883–07 NIDDK and RO1 GM121452 NIGMS to P.P., NIH F30 DE028206–01A1 NIDCR to E.A.P., NIH F32 GM125243–01A1 NIGMS to C.F.B. and EMBO postdoctoral fellowship and MDA Development Grant to E.B., Human Frontier Science Program (LT-000033/2019-L) to P.L.M. Author contributions: Conceptualization, E.A.P, C.F.B, P.P.; Methodology, E.A.P., C.F.B.; Formal Analysis, E.A.P., C.F.B.; Investigation, E.A.P., C.F.B, C.L., K.E.O.,E.B., P.L.M., M.J., R.P.L., K.R., P.M.W.; Resources, M.J., S.P.G, A.G.M, PP; Writing – Original Draft, E.A.P., C.F.B., P.P.; Writing – Review & Editing, E.A.P., C.F.B., P.P., K.O.M., E.A.P., E.B., P.L.M., C.L., M.J., R.P.L, K.R., P.M.W., A.G.M., PP; Visualization, E.A.P., C.F.B.; Supervision, E.A.P., C.F.B., P.P; Funding Acquisition , E.A.P. C.F.B., P.P."