Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation.

Authors:
Zhang JD; Liu J; Zhu SW; Fang Y; Wang B and 9 more

Journal:
Acta Pharmacol Sin

Publication Year: 2021

DOI:
10.1038/s41401-020-00601-4

PMCID:
PMC8563748

PMID:
33558654

Journal Information

Full Title: Acta Pharmacol Sin

Abbreviation: Acta Pharmacol Sin

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Pharmacology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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3/6
50.0% Transparent
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"Conflict of interest The authors declare that they have no conflict of interest."

Evidence found in paper:

"This work was supported by the National Natural Science Foundation of China (grant. No. 81670491) and National Key R&D Program of China (grant no. 2019YFA0905600). The authors would like to thank the Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences for their kindly help with the barostat used in the rat model and the Department of Neurobiology, Capital Medical University for their kindly provision of BV-2 cells. The authors would also like to thank the Metabolomics Facility at Technology Center for Protein Sciences in Tsinghua University, for their expert assistance with the determination of fecal SCFA."

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Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025