Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome.

"our first set of data demonstrated 1111 hypomethylated dmrs and 1696 hypermethylated dmrs (loci with a mehylation change >1 5-fold and an edge p value < 1 x 10 -4 ; supplementary fig s4a b and supplementary data 1 and 2 ) in thoracic aortas between f2 control and f2 lps-p offspring indicative of a global changed dna methylation occurring in pie f2 offspring.; signaling jak/stat signaling renin-angiotensin signaling lps-stimulated mapk signaling p53 signaling p70s6k signaling gpcr signaling and erk/mapk signaling pathways (fig 4f and supplementary data 3 ) [ ].; supplementary materials supplementary data 1 supplementary data 2 supplementary data 3 these authors contributed equally: xiao guan guo-rong dan yao yang yan ji supplementary information the online version contains supplementary material available at 10 1038/s41401-021-00772-8."

"Competing interests The authors declare no competing interests."

"This study was supported by National Natural Science Foundation of China (81773742, 81520108029), National Key Research and Development Project (2019YFA0111200, 2020YFA0113500), and Chongqing Science and Technology Commission of China (cstc2017jcyjBX0058)."