Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from <i>Pseudomonas aeruginosa</i>.

"The authors declare the following competing financial interest(s): The authors declare the following financial interest(s): C.K, I.W., J.K, J.H., R.W.H and A.K.H.H are co-inventors on a pending international patent application (PCT/EP2021/073381) that incorporates compounds and methods outlined in this manuscript."

"The authors thank Prof. Dr. Aránzazu Del Campo from Leibniz Institute for New Materials (INM) (Saarbrücken, Germany) for providing the NHDF cells, Khadidja Si Chaib for helping in testing the activity of the supernatant, and Martina Wiesbauer for the determination of ColH activities. They also thank the group of Susanne Häussler (Twincore, Hannover, Germany) for providing the P. aeruginosa ΔlasB PA14 strain. The authors are grateful for the technical support provided by Simone Amann, Jeannine Jung, Selina Wolter, and Dennis Jener. A.K.H.H. gratefully acknowledges funding from the Helmholtz Association’s Initiative and Networking Fund and by CARB-X. J.K. acknowledges funding by the Alexander von Humboldt Foundation and E.S. by the Austrian Science Fund (P 31843). Open Access is funded by the Austrian Science Fund (FWF)."