Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376.

"Competing interests The authors declare no competing interests."

"This work was supported by Beijing Natural Science Foundation (M21016 to SZ); CAMS Innovation Fund for Medical Sciences (2021-I2M-1-003 to SZ); CAMS Innovation Fund for Medical Sciences (2021-CAMS-JZ004 to SZ); Tsinghua University-Peking University Center for Life Sciences (045-61020100122 to SYZ) and Institute of biomedicine, Tsinghua University. We thank the assistance of Protein Preparation and Identification Facility at Technology Center for Protein Science of Tsinghua University. We appreciate the help from Genscript Biotech Co. Ltd for DNA synthesis, Vazyme Biotech Co. Ltd for offering ClonExpress II One Step Cloning Kit, NEST Biotechnology Co. Ltd for offering centrifugal tube and Topscience for offering GC376."