α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade.

"intensity ratios of pulldown/input bands are depicted in the bar plot (c) analysis of individual per patient paired ratio of st6gal1 to c5 mrna expression in whole blood of healthy controls ( n = 19) those with seasonal coronavirus ( n = 59) or those with covid-19 ( n = 46) from publicly available data set gene expression omnibus: gse161731.; publicly available whole-blood rna sequencing data and raw counts analyzed in this work were downloaded from gene expression omnibus (gse161731) published in a study by mcclain et al and analyzed in graphpad prism.; lectin microarray data for plasma samples and autopsy samples are available at synapse org (doi: 10 7303/syn27791795)."

"The authors declare no competing financial interest."

"The authors thank the Alberta Proteomics and Mass Spectrometry Facility for providing mass spectrometry services. The NYULH Center for Biospecimen Research and Development, Histology and Immunohistochemistry Laboratory (RRID:SCR_018304) is supported in part by the Laura and Isaac Perlmutter Cancer Center Support Grant (NIH/NCI P30CA016087). This project has been funded by the National Institute of Allergy and Infectious Diseases, a component of the NIH, Department of Health and Human Services, under Contract 75N93019C00052 (T.M.R and L.K.M.) and the Canada Excellence Research Chair Program (L.K.M.). Some graphical content was created with biorender.com."