Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells.

"The authors declare no competing financial interest."

"We would like to thank the uOttawa CBIA core (RRID: SCR_021845), funded by the University of Ottawa, Ottawa, Natural Sciences and engineering Research Council of Canada, and the Canada Foundation for Innovation, and core staff, Dr. Chloë van Oostende, Skye Green, and Redaet Daniel, as well as Vera Tang from the uOttawa Flow Cytometry and Virometry core for their technical support. We would also like to thank and acknowledge Dr. Shirley Qiu for technical advice and contribution to editing the manuscript and Dr. Suresh Gadde for providing advice and help with the manuscript. This research was funded by the Canadian Institutes of Health Research: grant number ER1-143489352509 and PJT155984390487 to M.C. and D.K., grant number 143521 to G.P.K., and part of this research was also supported by a COVID-19 Rapid Research grant (CIHR, OV3 170632) to M.C. and D.K.; C.M.S. was supported by a graduate scholarship from the Natural Sciences and Engineering Research Council of Canada and an Ontario Graduate Scholarship. K.Y.-P.A. was supported by a Centre for Catalysis Research Innovation (CCRI) Collaborative Research Award for Medicinal Chemistry. Support from the University of Ottawa to A.M.B. is gratefully acknowledged. K.F. was supported by an Ontario Graduate Scholarship. M.C. is a Canada Research Chair in Molecular Virology and Antiviral Therapeutics (950-232840) and recipients of Ontario Ministry of Research, Innovation and Science Early Researcher Awards (ER18-14-091). Additional support is provided to D.K. by the Public Health Agency of Canada."