A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish.

"availability of data and materials the whole-genome and whole-transcriptome sequencing data were deposited to sra under the bioproject accession no: prjna915203. availability of data and materials the whole-genome and whole-transcriptome sequencing data were deposited to sra under the bioproject accession no: prjna915203"

"Declarations Ethics approval and consent to participateInformed consent was obtained from the patients, for publication and genetic analyses. This study was performed in accordance with the Declaration of Helsinki. A blood sample was collected for DNA extraction, and informed consent was obtained from all study participants before the blood was drawn. Zebrafish were raised in accordance with Ulsan National Institute of Science and Technology and Use Committees (IACUC: UNISTIACUC-20-09). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research was supported by a Grant from Kyung Hee University in 2021 (KHU-20211823 to Y.L.) and the Institute for Basic Science (Grant Number IBS-R022-D1 to K.M.). This research was also partly supported by Basic Science Research Program through the NRF funded by the Ministry of Education (NRF-2021R1A6A3A13045998 to Y.C. and NRF-2018R1A6A1A03025810 to S.L.)."