Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas.

"the two newly generated scrna-seq datasets the integrated atlas and the reference mapped embedding of the feng dataset were deposited to the geo within super-series gse211799 . it is available as a curated resource in formats that enable interactive exploration via cellxgene and computational analyses ( https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas ) including access to the cellxgene curated dataset via sfaira .; data availability up-to-date data resource links are available from https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas .; the scarches model for reference mapping and an example code for reference mapping used for the feng dataset are available in https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas/tree/main/reference_mapping ."

"to empower future studies we also made mia available for both interactive and computational analyses (fig 1d ; https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas ).; it is available as a curated resource in formats that enable interactive exploration via cellxgene and computational analyses ( https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas ) including access to the cellxgene curated dataset via sfaira .; data availability up-to-date data resource links are available from https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas .; the scarches model for reference mapping and an example code for reference mapping used for the feng dataset are available in https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas/tree/main/reference_mapping .; code availability all code is available at https://github com/theislab/mouse_cross-condition_pancreatic_islet_atlas ."

"Competing interests F.J.T. consults for Immunai Inc., Singularity Bio B.V., CytoReason Ltd and Cellarity; and has an ownership interest in Dermagnostix GmbH and Cellarity. The remaining authors declare no competing interests."

"Funding Open access funding provided by Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)."