ANXA1 is identified as a key gene associated with high risk and T cell infiltration in primary sclerosing cholangitis.

"the microarray dataset gse159676 obtained from the geo database included 18 liver tissue samples12 from patients with psc and six from hc. availability of data and materials the datasets gse159676"

"Declarations Ethics approval and consent to participateThe study was approved by the Ethics Committee of Xiangya Hospital Central South University (No.202210226). The tissue samples involved in this study were from previous paraffin-embedded surgical or biopsy specimens derived from patients. All participants provided their written informed consent to participate in this study. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by National Natural Science Foundation of China (No. 81974080 and No. 82170640), WANG Bao-En Liver Fibrosis Research Fund (No.2021039), and Research and Development Plan in Key Areas of Science and Technology Department of Hunan Province (2020SK30272)."