Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids.

"availability of data and materials the dataset supporting the conclusions of this article is available in the ncbi bioproject database under accession number prjna954988 ( https://www ncbi nlm nih gov/bioproject/prjna954988 ). availability of data and materials the dataset supporting the conclusions of this article is available in the ncbi bioproject database under accession number prjna954988"

"code availability the code used in this study is available at github ( https://github com/jaeryuk/cfdna-organoid )."

"Declarations Ethics approval and consent to participateLung tissues were collected after written informed consent and approval from the ethical committee (IRB No. 2008-065-1148) at Seoul National University Bundang Hospital. Gastric normal tissues were collected after written informed consent and approval from the ethics committee (IRB No. 2010-178-1171) at Seoul National University Hospital. Gastric cancer tissues were collected after written informed consent and approval from the ethics committee (IRB No. 1805-151-948) at Seoul National University Hospital. The mouse xenoplantation experiment was conducted after receiving approval from the animal ethics committee (IACUC No. 17-0028-C1A8) at Seoul National University. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C1277); the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2020R1A6A1A03047972); a Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (2021R1A6C101A445); and an MD-PhD/Medical Scientist Training Program grant through the KHIDI, funded by the Ministry of Health & Welfare, Republic of Korea."