Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics.

"a one-way anova followed by dunnett's multiple comparisons test was used to calculate statistical significance in biofilm formation between the untreated control and antibiotic treated wells; none of the antibiotic treatment conditions showed a significant increase in biofilm formation (docx) click here for additional data file s1 file (txt) click here for additional data file s1 dataset excel file containing raw and normalized screening data (xlsx) click here for additional data file s2 dataset (xlsx) click here for additional data file s3 dataset (xlsx) click here for additional data file s4 dataset (xlsx) click here for additional data file s5 dataset (xlsx) click here for additional data file s6 dataset (xlsx) click here for additional data file s7 dataset (xlsx) click here for additional data file s8 dataset (xlsx) click here for additional data file s9 dataset (xlsx) click here for additional data file s10 dataset (xlsx) click here for additional data file s11 dataset (xlsx) click here for additional data file s12 dataset (xlsx) click here for additional data file s13 dataset (xlsx) click here for additional data file s14 dataset (xlsx) click here for additional data file s15 dataset (xlsx) click here for additional data file s16 dataset (xlsx) click here for additional data file. file s1 dataset excel file containing raw and normalized screening data (xlsx"

"The authors have declared that no competing interests exist."

"This work was funded by Natural Sciences and Engineering Research Council of Canada (www.nserc-crsng.gc.ca) grants RGPIN-2021-04237 to LLB and RGPIN-2019-07090 to EDB, and by infrastructure funding from Canada Foundation for Innovation and the Ontario Research Fund (ORF-RE09-047). LLB and EDB hold Tier I Canada Research Chairs in Microbe-Surface Interactions and Microbial Chemical Biology, respectively. LNY holds an NSERC PGS-D award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."