The chromatin landscape of the euryarchaeon Haloferax volcanii.

"availability of data and materials the sequencing datasets generated for this study can be accessed from geo accession gse207470 [ 78 ]. availability of data and materials the sequencing datasets generated for this study can be accessed from geo accession gse207470"

"Declarations Ethics approval and consent to participateNot applicable to this study. Competing interestsW.J.G. is a consultant and equity holder for 10x Genomics, Guardant Health, Quantapore, and Ultima Genomics and cofounder of Protillion Biosciences and is named on patents describing ATAC-seq.A.K. is a consulting Fellow with Illumina; a member of the SAB of OpenTargets (GSK), PatchBio, and SerImmune; and a scientific co-founder of RavelBio. Competing interests W.J.G. is a consultant and equity holder for 10x Genomics, Guardant Health, Quantapore, and Ultima Genomics and cofounder of Protillion Biosciences and is named on patents describing ATAC-seq. A.K. is a consulting Fellow with Illumina; a member of the SAB of OpenTargets (GSK), PatchBio, and SerImmune; and a scientific co-founder of RavelBio."

"The authors would like to thank Samuel Kim for input on the KAS-seq protocol, Matthew P. Swaffer for technical assistance, Zohar Shipony and members of the Greenleaf and Kundaje labs, and Tobias Warnecke, Fabian Blombach, and Anita Marchfelder for helpful discussions and suggestions for improvements to the text and analysis. This work was supported by NIH grants (P50HG007735, RO1 HG008140, U19AI057266, and UM1HG009442 to W.J.G.; 1UM1HG009436 to W.J.G. and A.K.; 1DP2OD022870-01 and 1U01HG009431 to A.K.), the Rita Allen Foundation (to W.J.G.), the Baxter Foundation Faculty Scholar Grant, and the Human Frontiers Science Program grant RGY006S (to W.J.G.). W.J.G. is a Chan Zuckerberg Biohub investigator and acknowledges grants 2017-174468 and 2018-182817 from the Chan Zuckerberg Initiative."