Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.

"reviewer #1: no reviewer #2: no ---------------------------------------------------- data deposition if you have submitted a research article or front matter that has associated data that are not suitable for deposition in a subject-specific public repository (such as genbank or arrayexpress) one way to make that data available is to deposit it in the dryad digital repository .; journalid=pgenetics&manu=pgenetics-d-23-00581r1 more information about depositing data in dryad is available at http://www datadryad org/depositing . file s1 file (xlsx"

"The authors have declared no competing interests."

"MESA and the MESA SHARe project are conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support for MESA is provided by contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC 95163, 75N92020D00004, N01-HC-95164, 5N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, UL1-TR-001881, and DK063491. The MESA Epigenomics & Transcriptomics Studies were funded by NIH grants 1R01HL101250, 1RF1AG054474, R01HL126477, R01DK101921, and R01HL135009. Co-authors of this manuscripts were partially supported by NHLBI grant R01HL141292, NSF grant DMS1712933, and NIH grants R01HG008773 and 1UG3CA267907. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."