Genome mining yields putative disease-associated ROMK variants with distinct defects.

"yours sincerely anne o'donnell-luria md phd academic editor plos genetics hua tang section editor plos genetics www plosgenetics org twitter: @plosgenetics ---------------------------------------------------- comments from the reviewers (if applicable): ---------------------------------------------------- data deposition if you have submitted a research article or front matter that has associated data that are not suitable for deposition in a subject-specific public repository (such as genbank or arrayexpress) one way to make that data available is to deposit it in the dryad digital repository .; journalid=pgenetics&manu=pgenetics-d-23-00911r1 more information about depositing data in dryad is available at http://www datadryad org/depositing . additional data are publicly available from github via the url: https://github com/mgm68/2023_romk_lof#2023_romk_lof .; additional data are publicly available from github via the url: https://github com/mgm68/2023_romk_lof#2023_romk_lof . xlsx) click here for additional data file s5"

"additional data are publicly available from github via the url: https://github com/mgm68/2023_romk_lof#2023_romk_lof .; additional data are publicly available from github via the url: https://github com/mgm68/2023_romk_lof#2023_romk_lof .; a comprehensive list of all scores computed by rhapsody for romk was deposited at https://github com/mgm68/2023_romk_lof/tree/main under the file name "rhapsody_all_predictions_romk"."

"I have read the journal’s policy and the authors of this manuscript have the following competing interests: S. Sarangi is an employee of Paradigm4, and Z.W.P. is a former employee of Paradigm4."

"This work was supported by grant GM131732 from the National Institutes of Health (NIH) to JLB, by grant DK079307 and DK137329 (Pittsburgh Center for Kidney Research) from the NIH to TRK, by grant DK129285 from the NIH to TRK and S. Sheng, and by award ID 826608 from the American Heart Association to NHN. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."