GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This research was supported by grants from the 10.13039/501100001809National Science Foundation of China (81974118, 82370879, 82100908), the Shanghai Outstanding Academic Leaders (20XD1433300), the Shuguang Project (21SG11), Innovative research team of high-level local universities in Shanghai (SHSMU-ZDCX20212700), Major Natural Science Project of the Scientific Research and Innovation Plan of Shanghai Municipal Commission of Education (2023ZKZD17), Shanghai Research Center for Endocrine and Metabolic Diseases (2022ZZ01002), 10.13039/501100013105Shanghai Rising-Star Program (23QA1407400), Shanghai Sixth People's Hospital Affiliated to 10.13039/501100004921Shanghai Jiao Tong University 10.13039/100008235School of Medicine (ynms202109), 10.13039/501100002858China Postdoctoral Science Foundation (2021M700088), and Shanghai Sixth People's Hospital Foundation (ynqn202106)."