Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.

"the mouse single cell rnaseq data are publicly available at https://umgear org/ ( https://identifiers org/geo:gse137299 https://identifiers org/geo:gse114157 https://identifiers org/geo:gse181454 https://identifiers org/geo:gse136196 ).; the mouse single cell rnaseq data are publicly available at https://umgear org/ ( https://identifiers org/geo:gse137299 https://identifiers org/geo:gse114157 https://identifiers org/geo:gse181454 https://identifiers org/geo:gse136196 ). c) shows the mean audiograms for the cases assigned to each category (error bars are standard error of the mean) (pdf) click here for additional data file s1 data (xlsx) click here for additional data file s2 data (xlsx) click here for additional data file s3 data (xlsx) click here for additional data file. s1 table (xlsx"

"The authors have declared that no competing interests exist."

"This work was primarily funded by the National Institutes of Health/National Institute on Deafness and Other Communication Disorders (P50 DC 000422 to JRD) awarded to the Medical University of South Carolina and by the South Carolina Clinical and Translational Research (SCTR) Institute, with an academic home at the Medical University of South Carolina, NIH/NCATS Grant number UL1 TR001450. This investigation was conducted in a facility constructed with support from Research Facilities Improvement Program Grant Number C06 RR14516 from the NIH/NCRR. TwinsUK is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), Zoe Ltd, the National Institute for Health and Care Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. The immunolabelling study was supported by RNID and In2Research UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."