Transfer learning with false negative control improves polygenic risk prediction.

"plos publication stage vor-update-to-uncorrected-proof publication update 2023-12-15 data availability o for simulation data the relevant r code used in the simulation are available at https://github com/jessiejeng/fnc-lasso o for the colaus/psycolaus data it can be applied from the database of genotypes and phenotypes (dbgap) (dbgap study accession: phs000145 v4 p2) at ncbi website: https://www ncbi nlm nih gov/projects/gap/cgi-bin/study cgi?; data availability o for simulation data the relevant r code used in the simulation are available at https://github com/jessiejeng/fnc-lasso o for the colaus/psycolaus data it can be applied from the database of genotypes and phenotypes (dbgap) (dbgap study accession: phs000145 v4 p2) at ncbi website: https://www ncbi nlm nih gov/projects/gap/cgi-bin/study cgi? plos publication stage vor-update-to-uncorrected-proof publication update 2023-12-15 data availability o for simulation data the relevant r code used in the simulation are available at https://github com/jessiejeng/fnc-lasso o for the colaus/psycolaus data it can be applied from the database of genotypes and phenotypes (dbgap) (dbgap study accession: phs000145 v4 p2) at ncbi website: https://www ncbi nlm nih gov/projects/gap/cgi-bin/study cgi?; data availability o for simulation data the relevant r code used in the simulation are available at https://github com/jessiejeng/fnc-lasso o for the colaus/psycolaus data it can be applied from the database of genotypes and phenotypes (dbgap) (dbgap study accession: phs000145 v4 p2) at ncbi website: https://www ncbi nlm nih gov/projects/gap/cgi-bin/study cgi? file s1 table (pdf) click here for additional data file s2 table (xlsx"

"plos publication stage vor-update-to-uncorrected-proof publication update 2023-12-15 data availability o for simulation data the relevant r code used in the simulation are available at https://github com/jessiejeng/fnc-lasso o for the colaus/psycolaus data it can be applied from the database of genotypes and phenotypes (dbgap) (dbgap study accession: phs000145 v4 p2) at ncbi website: https://www ncbi nlm nih gov/projects/gap/cgi-bin/study cgi?; data availability o for simulation data the relevant r code used in the simulation are available at https://github com/jessiejeng/fnc-lasso o for the colaus/psycolaus data it can be applied from the database of genotypes and phenotypes (dbgap) (dbgap study accession: phs000145 v4 p2) at ncbi website: https://www ncbi nlm nih gov/projects/gap/cgi-bin/study cgi?; the computer code for fnc+lasso together with complete documentation is publicly available at github: https://github com/jessiejeng/fnc-lasso ."

"The authors have declared that no competing interests exist."

"This work is partially supported by National Institutes of Health (https://www.nih.gov/) grants RF1AG074328 and U24AG041689 to JYT. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."