Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation.

"availability of data and materials data generated in this study are available at the ncbi gene expression omnibus ( https://www ncbi nlm nih gov/geo ) under accession number gse163021 [ 84 ]. availability of data and materials data generated in this study are available at the ncbi gene expression omnibus ( https://www ncbi nlm nih gov/geo ) under accession number gse163021"

"post-processing of vcf snps included additional filtering variant frequency calculation mapping variants to probes and mapping variants to public databases performed with a custom-written python script."

"Declarations Ethics approval and consent to participateTumor biopsies were collected as described [62]. Informed consent was obtained from all patients. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The European Research Council (ERC) Grant No. 724803 to A.H., the Israel Science Foundation Grant No. 948/16 and grant No. 3413/19 to A.H., and a grant from the Heidelberg Center for Personalized Oncology (DKFZ-HIPO) to B.R. supported this work."