Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.

"Declaration of competing interest The Icahn School of Medicine at Mount Sinai has filed patents on related work on behalf of AFS, PW and AGO. The other authors declare that they have no conflicts of interest for this study."

"We thank the Joslin Islet Isolation Core for rat islets. We acknowledge and thank the Einstein/Sinai Diabetes Center (ES-DRC) Human Islet and Adenoviral Core (HIAC) and other funding from NIDDK P30DK020541 (AGO, AFS, DKS), NIDDK R01DK126450 (DKS, AG-O), NIDDK R01DK116873 (AFS, DKS), NIDDK R01DK125285 (to AFS, AGO) 10.13039/100000062NIDDK R01DK129196 (to AFS, PW). Conceptualization, L.S.K. and D.K.S.; Methodology, L.S.K., G.B., P.W., J.M.H, C.B.N, D.K.S.; Investigation, L.S.K., G.B., P.W., P.Z., H.L., L.L.; Writing-Original Draft, L.S.K. and D.K.S.; Writing- Review and Editing, L.S.K., D.K.S., A.F.S., A.G-O; Supervision, C.B.N., A.F.S., A. G-O, D.K.S.; Funding Acquisition A.F.S., A.G-O., and D.K.S."