A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.

"the cell lysate was then analyzed with maldi using dhb matrix to identify the presence of the compound inside the cell 4 10 the coordinates for the complexed structures of human prmt3-ii710 (pdb id: 8g2f ) prmt3-yd1113 (pdb id: 8g2g ) prmt4-yd1113 (pdb id: 8g2h ) and prmt4 - yd1290 (pdb id: 8g2i ) have been deposited in the protein data bank."

"Conflict of interest The authors declare no competing financial interest."

"We are grateful to Purdue University Faculty Scholar program from the Ralph W. and Grace M. Showalter Trust and Department of Medicinal Chemistry and Molecular Pharmacology (to Rong Huang). The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, ikEsheiklman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome. We also appreciate valuable feedback from Dr. Akshay S. Kulkarni. This work was supported by Purdue University Faculty Scholar program from the Ralph W. and Grace M. Showalter Trust and Department of Medicinal Chemistry and Molecular Pharmacology (to Rong Huang). The authors acknowledge the support from NIH P30 CA023168 (Purdue University Center for Cancer Research), and the NSERC grant (RGPIN-2021-02728 (Jinrong Min))."