Integration of datasets for individual prediction of DNA methylation-based biomarkers.

"this code has also been deposited in zenodo under doi 10 5281/zenodo 10096139 [ 25 ]."

"all code is available with open access under the terms of the mit license at the following github repository: https://github com/marioni-group/dnam_projections_2023 [ 24 ]."

"Declarations Ethics approval and consent to participateAll components of GS received ethical approval from the NHS Tayside Committee on Medical Research Ethics (REC Reference Number: 05/S1401/89). GS has also been granted Research Tissue Bank status by the East of Scotland Research Ethics Service (REC Reference Number: 20-ES-0021), providing generic ethical approval for a wide range of uses within medical research.Ethical permission for the LBC1936 was obtained from the Multi-Centre Research Ethics Committee for Scotland (MREC/01/0/56) and the Lothian Research Ethics Committee (LREC/2003/2/29). Written informed consent was obtained from all participants.All experimental methods were in accordance with the Helsinki declaration. Competing interestsREM is a scientific advisor to the Epigenetic Clock Development Foundation and Optima Partners. DLM is a part-time employee of Optima Partners. RFH is a scientific advisor to Optima Partners. LM has received payment from Illumina for presentations and consultancy. Competing interests REM is a scientific advisor to the Epigenetic Clock Development Foundation and Optima Partners. DLM is a part-time employee of Optima Partners. RFH is a scientific advisor to Optima Partners. LM has received payment from Illumina for presentations and consultancy."

"Funding This research was funded in whole, or in part, by the Wellcome Trust (104036/Z/14/Z and 216767/Z/19/Z). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust [216767/Z/19/Z]. Genotyping of the GS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award ‘STratifying Resilience and Depression Longitudinally’ (STRADL) Reference 104036/Z/14/Z). The LBC1936 is supported by the Biotechnology and Biological Sciences Research Council, and the Economic and Social Research Council [BB/W008793/1], Age UK (Disconnected Mind project), the Milton Damerel Trust, and the University of Edinburgh. The LBC1921 was supported by the Biotechnology and Biological Sciences Research Council [SR176], the Chief Scientist Office of the Scottish Government [CZB/4/505; ETM/55], the Royal Society and the Medical Research Council [R42550]. Methylation typing was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. CM, TG, and BR are supported by the United Kingdom Research and Innovation (grant EP/S02431X/1), UKRI Centre for Doctoral Training in Biomedical AI at the University of Edinburgh, School of Informatics. REM is supported by Alzheimer’s Society major project grant AS-PG-19b-010."