Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis.

Authors:
Brown RDR; Green CD; Weigel C; Ni B; Celi FS and 2 more

Journal:
Mol Metab

Publication Year: 2023

DOI:
10.1016/j.molmet.2023.101851

PMCID:
PMC10772294

PMID:
38081412

Journal Information

Full Title: Mol Metab

Abbreviation: Mol Metab

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Metabolism

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
4/6
66.7% Transparent
Transparency Indicators
Click on green indicators to view evidence text
Core Indicators
Evidence found in paper:

"moreover analysis of publicly available data (bioproject: prjeb4337 from [ ]) revealed that tissue expression of ormdl3 but not ormdl1 or ormdl2 in humans is highest in metabolically active organs such as the liver and adipose tissue ( figure 1 b)."

Code Sharing
Evidence found in paper:

"Declaration of competing interest The authors have declared that no conflict of interest exists."

Evidence found in paper:

"This work was supported by the 10.13039/100000002National Institutes of Health under Grant R01GM043880 (S.S.), and by the Intramural Research Program of the 10.13039/100000062National Institute of Diabetes and Digestive and Kidney Diseases (R.L.P.). The authors acknowledge the 10.13039/100009238Virginia Commonwealth University Lipidomics/Metabolomics, Tissue and Data Acquisition and Analysis Core, and Microscopy Shared Resources, which were supported in part by funding from the NIH-NCI Cancer Center Support Grant P30 CA016059."

Protocol Registration
Open Access
Paper is freely available to read
Additional Indicators
Replication
Novelty Statement
Assessment Info

Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025