Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae.

"plos publication stage vor-update-to-uncorrected-proof publication update 2023-12-27 data availability rna-sequencing data is available at geo accession gse175398.; all flow cytometry data is deposited at flowrepository org and publicly accessible at http://flowrepository org/id/fr-fcm-z72g .; data availability rna-sequencing data is available at geo accession gse175398.; all flow cytometry data is deposited at flowrepository org and publicly accessible at http://flowrepository org/id/fr-fcm-z72g .; rna-sequencing data presented in this paper is a subset of the data described vande zande et al [ ] and are available at geo accession gse175398.; all flow cytometry data is deposited at flowrepository org and publicly accessible at http://flowrepository org/id/fr-fcm-z72g . code used for analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ).; code used for analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ).; code used in the analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ) s1 table table including all mutant strains of s cerevisiae used in this study including those for which rna-sequencing data was collected and strains bearing fluorescent protein reporters (xlsx) click here for additional data file s1 fig (a) population growth curves (measured using the optical density (od) at 660 nm) are shown for strains expressing a yellow fluorescent protein (yfp) driven by p tdh1 (light blue) p tdh2 (dark blue) or p tdh3 (black).; yours sincerely kelly a dyer section editor plos genetics justin fay section editor plos genetics www plosgenetics org twitter: @plosgenetics ---------------------------------------------------- comments from the reviewers (if applicable): ---------------------------------------------------- data deposition if you have submitted a research article or front matter that has associated data that are not suitable for deposition in a subject-specific public repository (such as genbank or arrayexpress) one way to make that data available is to deposit it in the dryad digital repository .; journalid=pgenetics&manu=pgenetics-d-23-01264 more information about depositing data in dryad is available at http://www datadryad org/depositing . code used in the analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ) s1 table table including all mutant strains of s cerevisiae used in this study including those for which rna-sequencing data was collected and strains bearing fluorescent protein reporters (xlsx) click here for additional data file s1 fig (a) population growth curves (measured using the optical density (od) at 660 nm) are shown for strains expressing a yellow fluorescent protein (yfp) driven by p tdh1 (light blue) p tdh2 (dark blue) or p tdh3 (black). xlsx) click here for additional data file s1 data availability rna-sequencing data is available at geo accession gse175398"

"code used for analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ).; code used for analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ).; code used in the analysis and to generate figures in this manuscript is available at github and in a permanent zenodo release (url: https://github com/pvz22/compensation_tdh3 zenodo doi: 10 5281/zenodo 10223579 ) s1 table table including all mutant strains of s cerevisiae used in this study including those for which rna-sequencing data was collected and strains bearing fluorescent protein reporters (xlsx) click here for additional data file s1 fig (a) population growth curves (measured using the optical density (od) at 660 nm) are shown for strains expressing a yellow fluorescent protein (yfp) driven by p tdh1 (light blue) p tdh2 (dark blue) or p tdh3 (black)."

"The authors have declared that no competing interests exist."

"This work was supported by the National Institutes of Health (T32GM07544 to P.V.Z; F32CA261115 to M.A.S; and R35GM118073 and R01GM108826 to P.J.W.) and the National Science Foundation (MCB-1929737 to P.J.W.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."