Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype.

"data availability raw reads and count matrices of snrna-seq data are publicly available at arrayexpress database under accession no. e-mtab-13032 and at www ebi ac uk/biostudies/arrayexpress/studies/e-mtab-13032 . data availability raw reads and count matrices of snrna-seq data are publicly available at arrayexpress database under accession no. e-mtab-13032"

"Competing interests M. Serrano is a shareholder of Senolytic Therapeutics, Life Biosciences, Rejuveron Senescence Therapeutics and Altos Labs and is an advisor to Rejuveron Senescence Therapeutics and Altos Labs. M. Serrano has been a consultant, until the end of 2022, for Rejuveron Senescence Therapeutics and Altos Labs. The funders had no role in the study design, data collection and analysis, decision to publish or manuscript preparation. The remaining authors declare no competing interests."

"We are grateful to K. Raj (Altos Laboratories) for his help with the experiments on replicative senescence. We thank D. Muñoz Espin (University of Cambridge) for sending us the IMR90 cells stably transduced with tamoxifen inducible Ras-G12V. We thank R. Mendez (IRB) for the H5V and HUVEC cells. We thank staff at the TEM-SEM Electron Microscopy Unit from Scientific and Technological Centers (CCiTUB), Universitat de Barcelona for their support and advice on TEM techniques. We are thankful to the Magnetic Resonance Imaging Core Facility of the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) for the scientific and technical support in MRI acquisition and analysis. M.M. received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement (no. 794744) and from the Spanish Ministry of Science and Innovation (MCIN) (RYC2020-030652-I/AEI/10.13039/501100011033). V.L.P. was a recipient of a predoctoral contract from the Spanish Ministry of Education (FPU-18/05917). K.M. was a recipient of fellowships from the German Cardiac, the German Research Foundation and a postdoctoral contract Juan de la Cierva from the MCIN. F.H.G. was supported by the PhD4MD Collaborative Research Training Program for Medical Doctors (IRB Barcelona/Hospital Clinic/IDIBAPS). M. Sanchez was funded by grants PID2021-122436OB-I00 from MCIN/AEI/10.13039/501100011033/FEDER, UE, RETOS COLABORACION RTC2019-007074-1 from MCIN/AEI/10.13039/501100011033. C.L.-M. was a recipient of a predoctoral contract from the Spanish Ministry of Education (FPU-18/02965). G.A. was funded by the Instituto de Salud Carlos III through project PI 20/01360, FEDER funds. J.M.C. was funded by the Instituto de Salud Carlos III through projects PI18/00910 and PI21/00931 (co-funded by European Regional Development Fund, a way to build Europe) and thanks the CERCA Programme/Generalitat de Catalunya for institutional support. Work in the laboratory of M. Serrano was funded by the IRB and ‘laCaixa’ Foundation and by grants from the Spanish Ministry of Science co-funded by the European Regional Development Fund (SAF2017-82613-R), European Research Council (ERC-2014-AdG/669622) and grant RETOS COLABORACION RTC2019-007125-1 from MCIN/AEI and Secretaria d’Universitats i Recerca del Departament d’Empresa i Coneixement of Catalonia (Grup de Recerca consolidat 2017 SGR 282)."