Adipose retinol saturase is regulated by β-adrenergic signaling and its deletion impairs lipolysis in adipocytes and acute cold tolerance in mice.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"Acknowledgements and funding We thank Dr. Patrick Seale (University of Pennsylvania) for providing murine SV40-immortalized brown adipogenic cells. We thank Dr. Susanne Keipert (Stockholm University) for valuable comments on energy metabolism in mice. We thank Dr. Achim Lass (University Graz) for helpful comments on the manuscript. This work was supported by the German Research Foundation (DFG, SCHU 2546/7-1 and SCHU 2546/9-1 to M.S., WO 2624/1-1 to S.J.W). This work was also supported by Chinese Scholarship Council stipends (to N.Y. and C.L.). K.M.P. was supported by the Sonnenfeld Foundation Berlin and M.F.K. and R.E.F. by Charité stipends. Chen Li: Data curation, Methodology, Writing – review & editing. Marie F. Kiefer: Data curation. Sarah Dittrich: Data curation. Roberto E. Flores: Data curation, Methodology. Yueming Meng: Data curation. Na Yang: Data curation. Sascha Wulff: Data curation. Sabrina Gohlke: Data curation. Manuela Sommerfeld: Data curation. Sylvia J. Wowro: Data curation, Funding acquisition. Konstantin M. Petricek: Data curation. Dominic Dürbeck: Data curation. Leonard Spranger: Data curation. Knut Mai: Data curation, Supervision. Holger Scholz: Conceptualization, Supervision, Writing – review & editing. Tim J. Schulz: Conceptualization, Data curation, Supervision, Writing – review & editing. Michael Schupp: Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing."