Activation of a non-neuronal cholinergic system in visceral white adipose tissue of obese mice and humans.

"Declaration of competing interest The authors declare that they have no competing interests."

"This work was supported by grants from 10.13039/501100006747Fondazione Cariverona (Bando Progetti Scientifici di Eccellenza 2018) to AG, Fondazione di Medicina Molecolare e Terapia Cellulare to AG, Progetti di Ricerca di Rilevante Interesse Nazionale (Prin) – Bando 2020 [Prot. 20205X4C9E] to EN, 10.13039/501100002803Cariplo Foundation (grant no. 2016-1006) to EN and AV, Umberto Veronesi Foundation to CR, Ministry of University and Research (MUR) Progetto Eccellenza (2023–2027) to the Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano (10.13039/501100011703LC, SP, GI, NM and MC) and by the Italian 10.13039/100009647Ministry of Health with Ricerca Corrente and 5 × 1000 funds to NM. The authors are very grateful to Dr Christian Dani for providing hMADS cells and to Dr Silvia Modena for her assistance with language and style. Ilenia Severi: Data curation, Investigation, Writing – original draft, Formal analysis, Methodology. Jessica Perugini: Data curation, Investigation, Writing – original draft, Formal analysis. Chiara Ruocco: Investigation, Methodology. Lara Coppi: Investigation, Methodology. Silvia Pedretti: Investigation, Methodology. Eleonora Di Mercurio: Investigation, Methodology. Martina Senzacqua: Investigation, Methodology. Maurizio Ragni: Investigation, Methodology. Gabriele Imperato: Investigation, Methodology. Alessandra Valerio: Supervision. Nico Mitro: Resources, Supervision, Funding acquisition. Maurizio Crestani: Resources, Supervision, Funding acquisition. Enzo Nisoli: Resources, Supervision, Funding acquisition. Antonio Giordano: Conception and design, Data analysis, Funding acquisition, Supervision, Resources, Manuscript writing."