Emergence and genomic characteristics of multi-drug-resistant <i>Salmonella</i> in pet turtles and children with diarrhoea.

"all newly sequenced data in this work were deposited in the national center for biotechnology information (ncbi) under the bioproject prjna833728. all accession numbers of the publicly available genomes were available in data set s1 available in the online version of this article.; thompson isolates from children <=5 years of age with diarrhoea were also collected in the enteric disease clinic of a hospital near the pet turtle sampling markets to investigate potential relationships of the dominant salmonella serovar between both origins (data set s1 and fig 1 ).; thompson isolates clustered with the chinese genomes were selected for the study (data set s1).; in total 42 acquired amr genes were detected (fig s1 and data set s1) along with a single mutation in the quinolone resistance-determining regions (qrdrs) gene gyra and two quaternary ammonium-resistant genes ( qacedelta1 and qacl ).; of these 26 types of resistant plasmids11 could be assigned the replicon types and 15 were non-typeable and were described with their names in the database of mob_suite (fig s1 and data set s1).; thompson isolates ( fig 4a b and data set s1).; thompson ( n =3) were found to have only one amino acid mutation (d165y) and were located in the same non-mobilizable plasmid (plasmid_566) sharing similar genetic structure as that of the plasmid of klebsiella pneumoniae isolate 11 (ow967038 1) ( figs5a s3a and data set s1).; among isolates in this study the types of virulence genes were similar and the number of virulence factors ranged between 99 and 113 (data set s1)."

"Conflicts of interest The author(s) declare that there are no conflicts of interest."

"Funding information This work was supported by the National Key R&D Program of China (grant 2020YFF0305002)."