Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.

"Declarations Ethics approval and consent to participateThe study involving human peripheral blood has been obtained according to consent regulation and approved by the Ethics Review Committee of Shanghai University of Traditional Chinese Medicine in Human Production authorized by Shanghai Municipal Government (No. 2018LCSY035); meanwhile, the informed consent has been provided by all patients conducted in accordance with the Declaration of Helsinki. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no conflicts of interest. Competing interests The authors declare that they have no conflicts of interest."

"Funding This work was supported by grant from the Shanghai local high level university gaofeng discipline (SJ007). And, this work was supported by grant from Traditional Chinese Medicine - traditional Chinese patent medicines and clinical evaluation platform (A1-U21-205-01010202)."