Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism.

"data availability data will be made available on request. acknowledgements we thank the for use of the ria biomarker core (p30-dk19525) and the (rrid:scr_022427"

"Declaration of competing interest None declared."

"We thank the University of Pennsylvania Diabetes Research Center (DRC) for use of the RIA Biomarker Core (P30-DK19525), and the University of Pennsylvania Rodent Metabolic Phenotyping Core (RRID:SCR_022427), supported in part by NIH grant S10-OD025098, for use of the EchoMRI to perform body composition measurements and for performing metabolic exercise performance experiments. This work was supported by National Institutes of Health Grants DK123252 (P.M.T.), Cox Research Institute and internal funds from the University of Pennsylvania (P.M.T.) Elizabeth Nunn: Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing. Natasha Jaiswal: Data curation, Formal analysis, Writing – review & editing. Matthew Gavin: Data curation, Investigation. Kahealani Uehara: Formal analysis, Investigation. Megan Stefkovich: Formal analysis, Investigation. Karima Drareni: Data curation, Formal analysis, Investigation. Ryan Calhoun: Formal analysis, Investigation. Michelle Lee: Data curation, Formal analysis. Corey D. Holman: Formal analysis, Investigation. Joseph A. Baur: Investigation, Writing – review & editing. Patrick Seale: Writing – review & editing. Paul M. Titchenell: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing."