Chromatin activity identifies differential gene regulation across human ancestries.

"all hichip reads are available as fastq files at ncbi sra project id prjna898623 [ 64 ].; ancestry associated differential expression data from single cell rna-seq in pbmcs is from randolph et al [ 40 ] available at ncbi geo accession no gse162632 [ 65 ] bqtl and h3k4me3 qtl are from supplemental table s1 of tehranchi et al [ 18 ]. all pipelines and code used for analyses in this paper are available on zenodo at https://zenodo org/records/10396417 and on github at https://github com/kadepettie/popabc/tree/master [ 66 ]."

"we used genrich (v0 5_dev available at https://github com/jsh58/genrich ) to call afr and eur atac-seq peaks jointly on the 8 samples from each with default parameters except for the following: -y -j -d 151.; all pipelines and code used for analyses in this paper are available on zenodo at https://zenodo org/records/10396417 and on github at https://github com/kadepettie/popabc/tree/master [ 66 ]. ancestry associated differential expression data from rna-seq in lcls after four-hour exposure to twelve cellular environments is from supplemental table s8 of lea et al [ 59 ] with additional files and analysis code at https://github com/amandajlea/lcls_gene_exp ."

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was funded by NIH grant R01GM134228. KPP was supported by NIH training grant T32GM007276 and the NSF Graduate Research Fellowship Program. HiChIP data generation was supported by NIH grant RM1-HG007735 to HYC."