A novel missense mutation (FGG c.1168G > T) in the gamma chain of fibrinogen causing congenital hypodysfibrinogenemia with bleeding phenotype.

"Declarations Ethics approval and consent to participateThis study was reviewed and approved by the Second Xiangya Hospital of Central South University Committee for Clinical Research, approval number NO. 2021830, and all methods were carried out under the Declaration of Helsinki. Besides, the written informed had been obtained from the patients. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research was supported by the Research Project of Health Commission of Hunan Province (Grant no.C202304077236), the Innovation and entrepreneurship education teaching reform research project of Central South University (Grant no.2022CG035), Hunan Provincial Natural Science Foundation of China (Grant no.2019JJ40440) and Fundamental Research Funds for the Central Universities of Central South University (Grant no.2022ZZTS0908)."