Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons.

"we further show that the high motivational state and sensitivity to stress is mediated by the disinhibition of a small population of neurons that express receptors for the fly homologue of neuropeptide y data availability data is available in a dryad repository ( https://doi org/10 5061/dryad pzgmsbctg ).; data availability data is available in a dryad repository ( https://doi org/10 5061/dryad pzgmsbctg ).; raw data of this manuscript is deposited at dryad digital repository [ ] https://doi org/10 5061/dryad pzgmsbctg [ ] s1 fig (tiff) click here for additional data file s2 fig data is represented as normalized z scores of 60 behavioral parameters n = 15 8 15 for mated naive-single and rejected respectively. file s1 table (xlsx data availability data is available in a dryad"

"The authors have declared that no competing interests exist."

"This work was supported by the Israel Science Foundation Grants (384/14 and 174/19 to GSO). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."