Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome.

"data availability statement data is publicly available at the gene expression omnibus (geo) under accession number #gse213366. data availability statement data is publicly available at the gene expression omnibus (geo) under accession number #gse213366"

"Disclosure statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"This is a retrospective study approved by the Institutional Review Board (IRB) of the University Hospital of Ribeirao Preto Medical School – University of São Paulo – USP (Protocol number: 031802/2018). This analysis included the participants of the observational clinical trials designed to evaluate the effects of supervised physical activity in PCOS properly registered as follows: (1) a nonrandomized single-arm, case-control investigation of progressive resistance training approved by our IRB (protocol no. 13475/2009) and registered at the Brazilian Clinical Trials Registry (ReBec, RBR-7p23c3) and (2) a randomized, controlled three-arm investigation of aerobic physical activity approved by our IRB (protocol no. 9640/2014) and registered at the Brazilian Clinical Trials Registry (ReBec, RBR-78qtwy) and the International Standard Randomized Controlled Trial Registry (ISRCTN10416750). Participants and/or their legal guardians provided written informed consent to participate in the Resistance and Aerobic Studies and waived signing a new form."