SURGE: uncovering context-specific genetic-regulation of gene expression from single-cell RNA sequencing using latent-factor models.

"the gtex v8 data [ 5 ] can be downloaded from the dbgap website under phs000424 v8 p2 and on the gtex portal ( http://gtexportal org/ ).; pbmc single-cell eqtl [ 18 ] expression data are available in the human cell atlas data coordination platform and at geo accession number gse174188.; pbmc single-cell eqtl [ 18 ] genotype data are available at dbgap accession number phs002812 v1 p1. additionally the surge source code used in this study is also accessible on zenodo ( https://doi org/ 10 5281/zenodo 10383060) [ 51 ]. surge can be applied any eqtl data set using publicly available software ( https://github com/bennystrobes/surge ) and can be scaled to tens of thousands of measurements (additional file 1 : fig s1).; availability of data and materials surge software is available on github at https://github com/bennystrobes/surge under an mit license."

"surge can be applied any eqtl data set using publicly available software ( https://github com/bennystrobes/surge ) and can be scaled to tens of thousands of measurements (additional file 1 : fig s1).; availability of data and materials surge software is available on github at https://github com/bennystrobes/surge under an mit license.; additionally the surge source code used in this study is also accessible on zenodo ( https://doi org/ 10 5281/zenodo 10383060) [ 51 ]."

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsAB is a shareholder of Alphabet, Inc., and a consultant for Third Rock Ventures. Competing interests AB is a shareholder of Alphabet, Inc., and a consultant for Third Rock Ventures."

"Funding AB was supported by NIH/NIGMS R35GM139580, NIH/NIDDK R01DK122586, and the Chan Zuckerberg Initiative. BJS was funded in part by U01 HG012009."