Mycobacterium tuberculosis response to cholesterol is integrated with environmental pH and potassium levels via a lipid metabolism regulator.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-05 data availability rna sequencing data have been deposited in the ncbi geo database (gse241072).; data availability rna sequencing data have been deposited in the ncbi geo database (gse241072). the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data .; the numerical data underlying the graphs shown in this figure are provided in s1 data (tif) click here for additional data file s2 fig log-phase wt ?; the numerical data underlying the graphs shown in this figure are provided in s1 data (tif) click here for additional data file s3 fig wt ?; the numerical data underlying the graphs shown in this figure are provided in s1 data (tif) click here for additional data file s4 fig wt ?; the numerical data underlying the graphs shown in this figure are provided in s1 data (tif) click here for additional data file s1 table (xlsx) click here for additional data file s2 table (xlsx) click here for additional data file s3 table (xlsx) click here for additional data file s4 table (xlsx) click here for additional data file s5 table (xlsx) click here for additional data file s6 table (xlsx) click here for additional data file s1 data excel file with numerical data underlying graphed data presented in all figure files (xlsx) click here for additional data file. file s1 table (xlsx data availability rna sequencing data have been deposited in the ncbi geo database (gse241072"

"The authors have declared that no competing interests exist."

"This work was supported by grants R01 AI143768 and R21 AI171356 from the National Institutes of Health (https://www.niaid.nih.gov/) to ST, and by a Natalie V. Zucker Research Center for Women Scholars Research Award from Tufts University School of Medicine (https://medicine.tufts.edu/information/faculty-staff/research-awards-grants) to YC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."