Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease.

"raw sequencing data for single-cell multiomes and snatac-seq are deposited in geo under accession number gse232222 [ 76 ].; raw sequencing and processed data for spatial visium libraries are deposited under accession number gse232431 [ 77 ]. code availability all of the code used to generate and analyze data in this manuscript is available on github ( https://github com/p4rkerw/wilson_gbio_2024 ) [ 74 ] and zenodo [ 75 ] under an open source compliant apache license version 2 0. code availability all of the code used to generate and analyze data in this manuscript is available on github ( https://github com/p4rkerw/wilson_gbio_2024 ) [ 74 ] and zenodo [ 75 ] under an open source compliant apache license version 2 0."

"the details of each analysis are outlined in the methods section and all of the code has been made publicly available on github.; code availability all of the code used to generate and analyze data in this manuscript is available on github ( https://github com/p4rkerw/wilson_gbio_2024 ) [ 74 ] and zenodo [ 75 ] under an open source compliant apache license version 2 0."

"Declarations Ethics approval and consent to participateThis research complies with all relevant ethical regulations and has been approved by the Washington University Institutional Review Board. Competing interestsB.D.H. is a consultant for Janssen Research & Development, LLC, Pfizer, and Chinook Therapeutics and holds equity in Chinook Therapeutics and grant funding from Janssen Research & Development, LLC, and Pfizer; all interests are unrelated to the current work. Competing interests B.D.H. is a consultant for Janssen Research & Development, LLC, Pfizer, and Chinook Therapeutics and holds equity in Chinook Therapeutics and grant funding from Janssen Research & Development, LLC, and Pfizer; all interests are unrelated to the current work."

"Funding These studies were supported by an NIH K08 Career Development Award (DK126847) to P.C.W. These studies were also supported by an NIH R01 (DK103740) and a Chan Zuckerberg Initiative seed network grant (CZF2019-002430) to B.D.H. The results are in part based upon data generated by KPMP: DK133081, DK133091, DK133092, DK133093, DK133095, DK1330971, DK114866, DK114908, DK133090, DK133113, DK133766, DK133768, DK114907, DK114920, DK114923, DK114933, DK114886. https://www.kpmp.org. KPMP data was downloaded on 2/23/2023."