Lipid metabolism-related genes are involved in the occurrence of asthma and regulate the immune microenvironment.

"availability of data and materials the datasets analysed during the current study are available in geo datasets gse74986 ( https://www ncbi nlm nih gov/geo/query/acc cgi? availability of data and materials the datasets analysed during the current study are available in geo datasets gse74986"

"Declarations Ethics approval and consent to participateAll experimental procedures were carried out in strict accordance with the protocol approved by the laboratory Animal Management Committee of Shandong University and experiments were carried out according to the regulations and guidelines established by this committee. All methods were reported in accordance with ARRIVE guidelines for the reporting of animal experiments. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National Natural Science Foundation of China (82172543), the Natural Science Foundation of Shandong Province (ZR2020MH006), Jinan City Health Commission Science and Technology Plan Project (2020–4-77) and the Humanities and Social Science Youth Team Project of Shandong University (IFYT1811, IFYT18036, and IFYT18037). The funding bodies were not involved in the design of the study, the collection, analysis, and interpretation of data or the preparation of the manuscript."