β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice.

"Declaration of competing interest The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article."

"We thank Ana Flete, Thomas Kolar, and Domenick Raphael for excellent technical support, as well as all members of the Pajvani, Accili and Siebel laboratories for insightful discussion. GFP-RelA was a gift from Warner Greene (Addgene plasmid # 23255). This research was supported by 10.13039/100000002NIH grants DK127862 (to NS), DK132661 (to UBP) and DK64819 (to DA), the Russell Berrie Foundation (to NS), and the Endocrine Fellows Foundation (to NS). JP Sulzerberger Columbia Genome Center performed RNA-Seq data analysis through the NIH/NCI Cancer Center Support Grant P30CA013696 using the Genomics and High Throughput Screening Shared Resource. The funding sources had no role in study design, collection, analysis and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. Nina Suda: Writing – review & editing, Writing – original draft, Visualization, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization. Alberto Bartolomé: Writing – review & editing, Methodology, Conceptualization. Jiani Liang: Writing – review & editing, Investigation. Jinsook Son: Writing – review & editing, Resources. Yoko Yagishita: Formal analysis, Writing – review & editing. Christian Siebel: Resources. Domenico Accili: Writing – review & editing, Methodology, Funding acquisition. Hongxu Ding: Resources, Formal analysis, Data curation. Utpal B. Pajvani: Writing – review & editing, Supervision, Methodology, Funding acquisition, Conceptualization."