Estimating the health impact of nicotine exposure by dissecting the effects of nicotine versus non-nicotine constituents of tobacco smoke: A multivariable Mendelian randomisation study.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-22 data availability data required to replicate all study findings reported in the article are provided on github at https://doi org/10 5281/zenodo 10469666 .; data availability data required to replicate all study findings reported in the article are provided on github at https://doi org/10 5281/zenodo 10469666 .; the statistical analysis was completed using the twosamplemr mvmr and mendelianrandomization packages and the statistical code and data used is available online ( https://doi org/10 5281/zenodo 10469666 ).; reviewer #1: no reviewer #2: no ---------------------------------------------------- data deposition if you have submitted a research article or front matter that has associated data that are not suitable for deposition in a subject-specific public repository (such as genbank or arrayexpress) one way to make that data available is to deposit it in the dryad digital repository .; journalid=pgenetics&manu=pgenetics-d-23-00895r1 more information about depositing data in dryad is available at http://www datadryad org/depositing . plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-22 data availability data required to replicate all study findings reported in the article are provided on github at https://doi org/10 5281/zenodo 10469666 .; data availability data required to replicate all study findings reported in the article are provided on github at https://doi org/10 5281/zenodo 10469666 . s1 table (xlsx data availability data required to replicate all study findings reported in the article are provided on github at https://doi"

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-02-22 data availability data required to replicate all study findings reported in the article are provided on github at https://doi org/10 5281/zenodo 10469666 .; data availability data required to replicate all study findings reported in the article are provided on github at https://doi org/10 5281/zenodo 10469666 ."

"The authors have declared that no competing interests exist."

"This work is supported by the Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol (MC_UU_00032/01, MC_UU_00032/04, MC_UU_00032/07). The salary of REW is funded by the Norwegian South-Eastern Regional Health Authority (2020024). This work was supported by Cancer Research UK (grant number C18281/A29019) who fund the salary of JNK and RCR. The salary of AET is funded by the European Research Council Advanced Grant (ART-Health; Grant ERC number 101021566). This work is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."