High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>.

"The authors declare no competing financial interest."

"We thank Selina Wolter, Jeannine Jung, Dennis Jener, Andreas M. Kany, and Jörg Haupenthal at the HIPS for performing the cytotoxicity, solubility, and metabolic stability assays and Ravindra P. Jumde for proofreading of the manuscript. This work has been supported by The Netherlands Organisation for Scientific Research (LIFT grant: 731.015.414, A.K.H.H. and R.M.G.) and the Helmholtz Association’s Initiative and Networking fund. D.Z. acknowledges support from the CSC Fellowship. A.R.O.J. is supported by NIH/NIAID R01-AI103280, R21-AI123808, and R21-AI130584 and is an Investigator in the Pathogenesis of Infectious Diseases (PATH) of the Burroughs Wellcome Fund. Furthermore, the authors acknowledge the financial support provided by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) via the grants 2015/26722-8, 2016/24790-9, 2017/03966-4, 2018/08820-0, and 2020/12277-0."