TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells.

"raw sequencing files and processed counts and bigwig files are available from geo superseries accession record gse236176 with subseries accession records gse236175 (atac-seq) gse236174 (chip-seq) gse236172 (time course pro-seq) and gse251772 (three clone pro-seq).; raw sequencing files and processed counts and bigwig files are available from geo superseries accession record gse236176 with subseries accession records gse236175 (atac-seq) gse236174 (chip-seq) gse236172 (time course pro-seq) and gse251772 (three clone pro-seq). reviewer #1: no reviewer #2: yes: elmar wolf reviewer #3: no ---------------------------------------------------- data deposition if you have submitted a research article or front matter that has associated data that are not suitable for deposition in a subject-specific public repository (such as genbank or arrayexpress) one way to make that data available is to deposit it in the dryad digital repository .; journalid=pgenetics&manu=pgenetics-d-23-01061r1 more information about depositing data in dryad is available at http://www datadryad org/depositing . plos publication stage vor-update-to-uncorrected-proof publication update 2024-03-01 data availability all analysis details and code are available at https://guertinlab github io/trps1_er_analysis/vignette html .; data availability all analysis details and code are available at https://guertinlab github io/trps1_er_analysis/vignette html . s1 table (txt) s2 table (txt) s3 table results generated using ame [ ] (csv"

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-03-01 data availability all analysis details and code are available at https://guertinlab github io/trps1_er_analysis/vignette html .; data availability all analysis details and code are available at https://guertinlab github io/trps1_er_analysis/vignette html .; details about each of the determined alleles are available at https://guertinlab github io/trps1_er_analysis/vignette html#allele-sequencing 8*10 5 cells per sample were plated in each well of a 6-well plate."

"The authors declare no competing interests."

"This work was funded by R35-GM128635 to MJG. 5T32GM007267-39 and 5T32GM008136-35 supported TGS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."