Anthracyclines induce cardiotoxicity through a shared gene expression response signature.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-03-11 data availability all rna-seq data have been deposited in the gene expression omnibus ( www ncbi nlm nih gov/geo/ ) under accession number gse243674.; data availability all rna-seq data have been deposited in the gene expression omnibus ( www ncbi nlm nih gov/geo/ ) under accession number gse243674. all custom analysis scripts used for this project are available at https://github com/mward-lab/matthews_top2i_cardiotox_2023 (doi 10 5281/zenodo 10637543 ) made possible by the workflowr package at https://doi org/10 12688%2ff1000research 20843 1 .; all custom analysis scripts used for this project are available at https://github com/mward-lab/matthews_top2i_cardiotox_2023 (doi 10 5281/zenodo 10637543 ) made possible by the workflowr package at https://doi org/10 12688%2ff1000research 20843 1 .; yours sincerely anna di rienzo academic editor plos genetics david kwiatkowski section editor plos genetics www plosgenetics org twitter: @plosgenetics ---------------------------------------------------- comments from the reviewers (if applicable): ---------------------------------------------------- data deposition if you have submitted a research article or front matter that has associated data that are not suitable for deposition in a subject-specific public repository (such as genbank or arrayexpress) one way to make that data available is to deposit it in the dryad digital repository .; journalid=pgenetics&manu=pgenetics-d-23-01098r1 more information about depositing data in dryad is available at http://www datadryad org/depositing . s1 table data related to figs1b s2 s3 and s4 (xlsx data availability all rna-seq data have been deposited in the gene expression omnibus ( www ncbi nlm nih gov/geo/ ) under accession number gse243674"

"all custom analysis scripts used for this project are available at https://github com/mward-lab/matthews_top2i_cardiotox_2023 (doi 10 5281/zenodo 10637543 ) made possible by the workflowr package at https://doi org/10 12688%2ff1000research 20843 1 .; all custom analysis scripts used for this project are available at https://github com/mward-lab/matthews_top2i_cardiotox_2023 (doi 10 5281/zenodo 10637543 ) made possible by the workflowr package at https://doi org/10 12688%2ff1000research 20843 1 ."

"The authors have declared that no competing interests exist."

"This work was funded by a Cancer Prevention Research Institute of Texas (https://www.cprit.state.tx.us/) Recruitment of First-Time Faculty Award (RR190110) to M.C.W. O.D.J was supported by a Jeane B. Kempner Predoctoral Fellowship administered through UTMB (http://www.kempnerfund.org/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. S.R.P was supported by an NSF (http://www.nsf.gov) grant (NSF1933321) to Dr. Stefan Bossman (PI)."