Characterization and mitigation of artifacts derived from NGS library preparation due to structure-specific sequences in the human genome.

"availability of data and materials the datasets generated and/or analysed during the current study are available in the genome sequence archive (gsa) repository accession number: prjca020370. availability of data and materials the datasets generated and/or analysed during the current study are available in the genome sequence archive (gsa) repository accession number: prjca020370"

"we are providing artifactsfinder freely available on github at https://github com/lilicai/artifactsfinder ."

"Declarations Ethics approval and consent to participateThis study was approved by the Ethics Committee of Jinshan hospital (No. JIEC 2022-S27). Written informed consent was obtained from each patient and the methods were carried out in accordance with approved guidelines. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by Cancer Genome Atlas of China (CGAC) project (YCZYPT [2018]06) from the National Human Genetic Resources Sharing Service Platform (2005DKA21300)."